Discussion: Redundancy by Design

There is redundancy in the genetic code, in the receptors and proteins, and the neurons in the brain. Developmentally, the brain makes more neurons than needed and then prunes the unnecessary elements, commonly known as the “use it or lose it” rule. If you do not see...

Air pollution is associated with sex‐specific longitudinal changes in astrocytic and neuroinflammatory processes linked to cognitive decline in Alzheimer’s disease at‐risk individuals

Abstract INTRODUCTION Air pollution is associated with dementia risk, but its role during preclinical Alzheimer’s disease (AD) remains unclear. METHODS We examined long-term residential exposure to traffic-related air pollution in 226 cognitively unimpaired...