Abstract
INTRODUCTION
Detection of Alzheimer’s disease (AD) pathophysiology among individuals with mild cognitive changes and those experiencing subjective cognitive decline (SCD) remains challenging. Plasma phosphorylated tau 217 (p-tau217) is one of the most promising of the emerging biomarkers for AD. However, accessible methods are limited.
METHODS
We employed a novel p-tau217 immunoassay (University of Gothenburg [UGOT] p-tau217) in four independent cohorts (n = 308) including a cerebrospinal fluid (CSF) biomarker-classified cohort (Discovery), two cohorts consisting mostly of cognitively unimpaired (CU) and mild cognitively impaired (MCI) participants (MYHAT and Pittsburgh), and a population-based cohort of individuals with SCD (Barcelonaβeta Brain Research Center’s Alzheimer’s At-Risk Cohort [β-AARC]).
RESULTS
UGOT p-tau217 showed high accuracy (area under the curve [AUC] = 0.80–0.91) identifying amyloid beta (Aβ) pathology, determined either by Aβ positron emission tomography or CSF Aβ42/40 ratio. In individuals experiencing SCD, UGOT p-tau217 showed high accuracy identifying those with a positive CSF Aβ42/40 ratio (AUC = 0.91).
DISCUSSION
UGOT p-tau217 can be an easily accessible and efficient way to screen and monitor patients with suspected AD pathophysiology, even in the early stages of the continuum.
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This post is Copyright: Fernando Gonzalez‐Ortiz,
Pamela C. L. Ferreira,
Armand González‐Escalante,
Laia Montoliu‐Gaya,
Paula Ortiz‐Romero,
Przemyslaw R. Kac,
Michael Turton,
Hlin Kvartsberg,
Nicholas J. Ashton,
Henrik Zetterberg,
Peter Harrison,
Bruna Bellaver,
Guilherme Povala,
Victor L. Villemagne,
Tharick A. Pascoal,
Mary Ganguli,
Anne D. Cohen,
Carolina Minguillon,
Jose Contador,
Marc Suárez‐Calvet,
Thomas K. Karikari,
Kaj Blennow | November 17, 2023