We aimed to describe baseline amyloid-beta (Aβ) and tau-positron emission tomograrphy (PET) from Longitudinal Early-onset Alzheimer’s Disease Study (LEADS), a prospective multi-site observational study of sporadic early-onset Alzheimer’s disease (EOAD).
We analyzed baseline [18F]Florbetaben (Aβ) and [18F]Flortaucipir (tau)-PET from cognitively impaired participants with a clinical diagnosis of mild cognitive impairment (MCI) or AD dementia aged < 65 years. Florbetaben scans were used to distinguish cognitively impaired participants with EOAD (Aβ+) from EOnonAD (Aβ−) based on the combination of visual read by expert reader and image quantification.
243/321 (75.7%) of participants were assigned to the EOAD group based on amyloid-PET; 231 (95.1%) of them were tau-PET positive (A+T+). Tau-PET signal was elevated across cortical regions with a parietal-predominant pattern, and higher burden was observed in younger and female EOAD participants.
LEADS data emphasizes the importance of biomarkers to enhance diagnostic accuracy in EOAD. The advanced tau-PET binding at baseline might have implications for therapeutic strategies in patients with EOAD.

72% of patients with clinical EOAD were positive on both amyloid- and tau-PET.
Amyloid-positive patients with EOAD had high tau-PET signal across cortical regions.
In EOAD, tau-PET mediated the relationship between amyloid-PET and MMSE.
Among EOAD patients, younger onset and female sex were associated with higher tau-PET.

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This post is Copyright: Hanna Cho,
Nidhi S. Mundada,
Liana G. Apostolova,
Maria C. Carrillo,
Ranjani Shankar,
Alinda N. Amuiri,
Ehud Zeltzer,
Charles C. Windon,
David N. Soleimani‐Meigooni,
Jeremy A. Tanner,
Courtney Lawhn Heath,
Orit H. Lesman‐Segev,
Paul Aisen,
Ani Eloyan,
Hye Sun Lee,
Dustin B. Hammers,
Kala Kirby,
Jeffrey L. Dage,
Anne Fagan,
Tatiana Foroud,
Lea T. Grinberg,
Clifford R. Jack,
Joel Kramer,
Walter A. Kukull,
Melissa E. Murray,
Kelly Nudelman,
Arthur Toga,
Prashanthi Vemuri,
Alireza Atri,
Gregory S. Day,
Ranjan Duara,
Neill R. Graff‐Radford,
Lawrence S. Honig,
David T. Jones,
Joseph Masdeu,
Mario Mendez,
Erik Musiek,
Chiadi U. Onyike,
Meghan Riddle,
Emily J. Rogalski,
Stephen Salloway,
Sharon Sha,
Raymond Scott Turner,
Thomas S. Wingo,
David A. Wolk,
Robert Koeppe,
Leonardo Iaccarino,
Bradford C. Dickerson,
Renaud La Joie,
Gil D. Rabinovici,
LEADS Consortium | September 10, 2023

Wiley: Alzheimer’s & Dementia: Table of Contents