Abstract
INTRODUCTION
Alzheimer’s disease (AD) and AD-related dementias (ADRD) are leading causes of death among older adults in the United States. Efforts to understand risk factors for prevention are needed.
METHODS
Participants (n = 146,166) enrolled in the Women’s Health Initiative without AD at baseline were included. Diabetes status was ascertained from self-reported questionnaires and deaths attributed to AD/ADRD from hospital, autopsy, and death records. Competing risk regression models were used to estimate the cause-specific hazard ratios (HRs) and 95% confidence intervals (CIs) for the prospective association of type 2 diabetes mellitus (T2DM) with AD/ADRD and non-AD/ADRD mortality.
RESULTS
There were 29,393 treated T2DM cases and 8628 AD/ADRD deaths during 21.6 (14.0–23.5) median (IQR) years of follow-up. Fully adjusted HRs (95% CIs) of the association with T2DM were 2.94 (2.76–3.12) for AD/ADRD and 2.65 (2.60–2.71) for the competing risk of non-AD/ADRD mortality.
DISCUSSION
T2DM is associated with AD/ADRD and non-AD/ADRD mortality.
Highlights
Type 2 diabetes mellitus is more strongly associated with Alzheimer’s disease (AD)/AD and related dementias (ADRD) mortality compared to the competing risk of non-AD/ADRD mortality among postmenopausal women.
This relationship was consistent for AD and ADRD, respectively.
This association is strongest among participants without obesity or hypertension and with younger age at baseline, higher diet quality, higher physical activity, higher alcohol consumption, and older age at the time of diagnosis of type 2 diabetes mellitus.
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This post is Copyright: Tyler J. Titcomb,
Phyllis Richey,
Ramon Casanova,
Lawrence S. Phillips,
Simin Liu,
Shama D. Karanth,
Nazmus Saquib,
Tomas Nuño,
JoAnn E. Manson,
Aladdin H. Shadyab,
Longjian Liu,
Terry L. Wahls,
Linda G. Snetselaar,
Robert B. Wallace,
Wei Bao | August 11, 2023