Among older adults, total and hospitalized infection may be associated with incidence of all-cause and Alzheimer’s disease (AD) dementias, with variation by cardiovascular health (CVH).
We used Cox proportional hazards (PH) models to examine the relationships between International Classification of Diseases-10th revision (ICD-10)-specific viral and bacterial infectious agents and incident all-cause and AD dementia among 355,046 UK Biobank participants ≥50 years at baseline. Life’s Essential 8 (LE8) index reflected CVH.
In both sexes, total infection burden (yes vs. no) was associated with all-cause dementia, with significant interactions by LE8 tertiles, whereby this relationship was significant only in the lowest LE8 tertile. Hospital-treated infection burden (yes vs no) was significantly related to all-cause and AD dementia, with no significant interaction with LE8 tertile. Age group patterns were detected.
AD and all-cause dementia were related to hospital-treated infections, while CVH modified the relationship of total infection burden with all-cause dementia.

Secondary analysis on >355,000 UK Biobank participants ≥50 years at baseline.
Alzheimer’s disease and all-cause dementia are both related to hospital-treated infection.
Cardiovascular health modifies association of infection burden with all-cause dementia.

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This post is Copyright: Hind A. Beydoun,
May A. Beydoun,
Osorio Meirelles,
Lance D. Erickson,
Alyssa A. Gamaldo,
Jordan Weiss,
Lenore J. Launer,
Michele K. Evans,
Alan B. Zonderman | August 7, 2023

Wiley: Alzheimer’s & Dementia: Table of Contents