The Rey Auditory Verbal Learning Test (RAVLT) is a useful neuropsychological test for describing episodic memory impairment in dementia. However, there is limited research on its utility in early-onset Alzheimer’s disease (EOAD). We assess the influence of amyloid and diagnostic syndrome on several memory scores in EOAD.
We transcribed RAVLT recordings from 303 subjects in the Longitudinal Early-Onset Alzheimer’s Disease Study. Subjects were grouped by amyloid status and syndrome. Primacy, recency, J-curve, duration, stopping time, and speed score were calculated and entered into linear mixed effects models as dependent variables.
Compared with amyloid negative subjects, positive subjects exhibited effects on raw score, primacy, recency, and stopping time. Inter-syndromic differences were noted with raw score, primacy, recency, J-curve, and stopping time.
RAVLT measures are sensitive to the effects of amyloid and syndrome in EOAD. Future work is needed to quantify the predictive value of these scores.

RAVLT patterns characterize various presentations of EOAD and EOnonAD
Amyloid impacts raw score, primacy, recency, and stopping time
Timing-based scores add value over traditional count-based scores

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This post is Copyright: Justin Bushnell,
Dustin B. Hammers,
Paul Aisen,
Jeffrey L. Dage,
Ani Eloyan,
Tatiana Foroud,
Lea T. Grinberg,
Leonardo Iaccarino,
Clifford R. Jack,
Kala Kirby,
Joel Kramer,
Robert Koeppe,
Walter A. Kukull,
Renaud La Joie,
Nidhi S. Mundada,
Melissa E. Murray,
Kelly Nudelman,
Malia Rumbaugh,
David N. Soleimani‐Meigooni,
Arthur Toga,
Alexandra Touroutoglou,
Prashanthi Vemuri,
Alireza Atri,
Gregory S. Day,
Ranjan Duara,
Neill R. Graff‐Radford,
Lawrence S. Honig,
David T. Jones,
Joseph Masdeu,
Mario Mendez,
Erik Musiek,
Chiadi U. Onyike,
Meghan Riddle,
Emily Rogalski,
Steven Salloway,
Sharon Sha,
Raymond S. Turner,
Thomas S. Wingo,
David A. Wolk,
Maria C. Carrillo,
Bradford C. Dickerson,
Gil D. Rabinovici,
Liana G. Apostolova,
David G. Clark,
the LEADS Consortium | September 1, 2023

Wiley: Alzheimer’s & Dementia: Table of Contents