Abstract
INTRODUCTION
The timing of plasma biomarker changes is not well understood. The goal of this study was to evaluate the temporal co-evolution of plasma and positron emission tomography (PET) Alzheimer’s disease (AD) biomarkers.
METHODS
We included 1408 Mayo Clinic Study of Aging and Alzheimer’s Disease Research Center participants. An accelerated failure time (AFT) model was fit with amyloid beta (Aβ) PET, tau PET, plasma p-tau217, p-tau181, and glial fibrillary acidic protein (GFAP) as endpoints.
RESULTS
Individual timing of plasma p-tau progression was strongly associated with Aβ PET and GFAP progression. In the population, GFAP became abnormal first, then Aβ PET, plasma p-tau, and tau PET temporal meta-regions of interest when applying cut points based on young, cognitively unimpaired participants.
DISCUSSION
Plasma p-tau is a stronger indicator of a temporally linked response to elevated brain Aβ than of tau pathology. While Aβ deposition and a rise in GFAP are upstream events associated with tau phosphorylation, the temporal link between p-tau and Aβ PET was the strongest.
HIGHLIGHTS
Plasma p-tau progression was more strongly associated with Aβ than tau PET.
Progression on plasma p-tau was associated with Aβ PET and GFAP progression.
P-tau181 and p-tau217 become abnormal after Aβ PET and before tau PET.
GFAP became abnormal first, before plasma p-tau and Aβ PET.
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This post is Copyright: Petrice M. Cogswell,
Emily S. Lundt,
Terry M. Therneau,
Heather J. Wiste,
Jonathan Graff‐Radford,
Alicia Algeciras‐Schimnich,
Val J. Lowe,
Michelle M. Mielke,
Christopher G. Schwarz,
Matthew L. Senjem,
Jeffrey L. Gunter,
David S. Knopman,
Prashanthi Vemuri,
Ronald C. Petersen,
Clifford R. Jack Jr | November 15, 2023