Inferring the timeline from mild cognitive impairment (MCI) to severe dementia is pivotal for patients, clinicians, and researchers. Literature is sparse and often contains few patients. We aim to determine the time spent in MCI, mild-, moderate-, severe dementia, and institutionalization until death.
Multistate modeling with Cox regression was used to obtain the sojourn time. Covariates were age at baseline, sex, amyloid status, and Alzheimer’s disease (AD) or other dementia diagnosis. The sample included a register (SveDem) and memory clinics (Amsterdam Dementia Cohort and Memento).
Using 80,543 patients, the sojourn time from clinically identified MCI to death across all patient groups ranged from 6.20 (95% confidence interval [CI]: 5.57–6.98) to 10.08 (8.94–12.18) years.
Generally, sojourn time was inversely associated with older age at baseline, males, and AD diagnosis. The results provide key estimates for researchers and clinicians to estimate prognosis.

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This post is Copyright: Ashley E Tate,
Vincent Bouteloup,
Ingrid S. van Maurik,
Delphine Jean,
Arenda Mank,
Andreja Speh,
Valerie Boilet,
Argonde van Harten,
Maria Eriksdotter,
Anders Wimo,
Carole Dufouil,
Wiesje M. van der Flier,
Linus Jönsson | October 2, 2023

Wiley: Alzheimer’s & Dementia: Table of Contents