The retina may provide non-invasive, scalable biomarkers for monitoring cerebral neurodegeneration.
We used cross-sectional data from The Maastricht study (n = 3436; mean age 59.3 years; 48% men; and 21% with type 2 diabetes [the latter oversampled by design]). We evaluated associations of retinal nerve fiber layer, ganglion cell layer, and inner plexiform layer thicknesses with cognitive performance and magnetic resonance imaging indices (global grey and white matter volume, hippocampal volume, whole brain node degree, global efficiency, clustering coefficient, and local efficiency).
After adjustment, lower thicknesses of most inner retinal layers were significantly associated with worse cognitive performance, lower grey and white matter volume, lower hippocampal volume, and worse brain white matter network structure assessed from lower whole brain node degree, lower global efficiency, higher clustering coefficient, and higher local efficiency.
The retina may provide biomarkers that are informative of cerebral neurodegenerative changes in the pathobiology of dementia.

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This post is Copyright: Frank C. T. Heide,
Indra L. M. Steens,
Betsie Limmen,
Sara Mokhtar,
Martin P. J. Boxtel,
Miranda T. Schram,
Sebastian Köhler,
Abraham A. Kroon,
Carla J. H. Kallen,
Pieter C. Dagnelie,
Martien C. J. M. Dongen,
Simone J. P. M. Eussen,
Tos T. J. M. Berendschot,
Carroll A. B. Webers,
Marleen M. J. Greevenbroek,
Annemarie Koster,
Thomas T. Sloten,
Jacobus F. A. Jansen,
Walter H. Backes,
Coen D. A. Stehouwer | August 24, 2023

Wiley: Alzheimer’s & Dementia: Table of Contents