Nature Neuroscience, Published online: 24 August 2023; doi:10.1038/s41593-023-01417-1We developed a 3D human neuroimmune axis model to study the interplay of brain innate immune cells and peripheral adaptive immune cells in Alzheimer’s disease. Alzheimer’s disease pathology induced a marked increase in CD8+ T cell infiltration, exacerbating neurodegeneration. The CXCL10–CXCR3 pathway has a key role in mediating this process.

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This post is Copyright: | August 24, 2023
Nature Neuroscience