Modeling maternal immune activation in 3D ex vivo human fetal brain cerebroids reveals IL-17A-driven disruption of cortical development

by Clinical Neuropsychologist Online | Tuesday, August 11, 2026 | Neuroscience

Nature Neuroscience, Published online: 11 August 2026; doi:10.1038/s41593-026-02400-2Using cerebroids, a 3D ex vivo model of the human fetal brain, the authors show that IL-17A, a mediator of maternal immune activation linked to neurodevelopmental disorders, disrupts...

Susumu Tonegawa (1939–2026)

by Clinical Neuropsychologist Online | Tuesday, August 11, 2026 | Neuroscience

Nature Neuroscience, Published online: 11 August 2026; doi:10.1038/s41593-026-02416-8On 11 July 2026, neuroscience lost one of its most visionary scientists with the passing of Susumu Tonegawa at the age of 86. Across an extraordinary career spanning more than five...

Pyramidal cell types and circuit organization of the mouse insular cortex reveal functional specializations

by Clinical Neuropsychologist Online | Friday, August 7, 2026 | Neuroscience

Nature Neuroscience, Published online: 07 August 2026; doi:10.1038/s41593-026-02391-0A multimodal cell-type atlas of the mouse insular cortex reveals specialized pyramidal types and circuits in distinct insular subregions, as well as intra-insular functional...

Striatal endocannabinoids drive one-shot learning

by Clinical Neuropsychologist Online | Friday, August 7, 2026 | Neuroscience

Nature Neuroscience, Published online: 07 August 2026; doi:10.1038/s41593-026-02392-zEndocannabinoid-dependent corticostriatal plasticity underlies avoidance learning in mice after a single experience. Disrupting this process impairs learning, revealing a nonclassical...

A suite of engineered mice for interrogating psychedelic drug actions

by Clinical Neuropsychologist Online | Thursday, August 6, 2026 | Neuroscience

Nature Neuroscience, Published online: 06 August 2026; doi:10.1038/s41593-026-02375-0Chiu et al. have developed engineered HTR2A mouse lines enabling in vivo mapping, targeting and modulation of receptor-expressing neurons and validated their utility across...

Neuroligin-3–CSPG4 interaction maintains oligodendrocyte precursor cell progenitor state and promotes glioma proliferation through mechanotransduction

by Clinical Neuropsychologist Online | Thursday, August 6, 2026 | Neuroscience

Nature Neuroscience, Published online: 06 August 2026; doi:10.1038/s41593-026-02397-8This study finds that shed NLGN3 interacts with the glycosylated surface protein CSPG4 on both normal and malignant glial cells, activating mechanotransduction pathways that drive...