Foamy microglia link oxylipins to disease progression in multiple sclerosis

by Clinical Neuropsychologist Online | Thursday, May 21, 2026 | Neuroscience

Nature Neuroscience, Published online: 21 May 2026; doi:10.1038/s41593-026-02302-3Foamy microglia are associated with multiple sclerosis progression, linking phagocytosis, altered lipid metabolism (oxylipins) and lysosomal stress to nonclassical neuroinflammation and...

Why Brain Lipids Matter: The Hidden Players in Brain Health

by Clinical Neuropsychologist Online | Wednesday, May 20, 2026 | Neuroscience

Migraine – a particular type of headache that can come with visual, sensory, and other symptoms—; strikes one in seven people worldwide. Researchers believe that migraine symptoms are caused by ;neurogenic ;inflammation along with vascular changes in the brain, but...

Tau aggregates cause reactivation of transposable DNA elements, leading to Z-RNA–ZBP1-mediated neuronal death

by Clinical Neuropsychologist Online | Wednesday, May 20, 2026 | Neuroscience

Nature Neuroscience, Published online: 20 May 2026; doi:10.1038/s41593-026-02299-9Tau aggregates disrupt heterochromatin by sequestering H3K9me3, reactivating transposable elements. This generates Z-RNAs, activating ZBP1 to drive neuronal death. ZBP1...

Considering biological limitations of lesion network mapping

by Clinical Neuropsychologist Online | Wednesday, May 20, 2026 | Neuroscience

Nature Neuroscience, Published online: 20 May 2026; doi:10.1038/s41593-026-02319-8Lesion network mapping (LNM), or atrophy network mapping, has become a widely adopted tool for linking focal brain lesions or neurodegenerative brain clusters, respectively, to...

Spatial proteomic analysis in human Alzheimer’s disease brains enables identification of microenvironment-dependent microglial cell states

by Clinical Neuropsychologist Online | Monday, May 18, 2026 | Neuroscience

Nature Neuroscience, Published online: 18 May 2026; doi:10.1038/s41593-026-02267-3Myeloid cells show marked heterogeneity in Alzheimer’s disease. This study introduces CODEX-CNS, a single-cell spatial proteomics pipeline, and identifies a human microglial...

Autism subtypes identified using cross-species functional connectivity analyses

by Clinical Neuropsychologist Online | Friday, May 15, 2026 | Neuroscience

Nature Neuroscience, Published online: 15 May 2026; doi:10.1038/s41593-026-02287-zPagani et al. used cross-species fMRI to reveal two autism subtypes, characterized by lower and higher brain connectivity and linked to synaptic and immune-related pathways,...