Elucidating the neuropathological and molecular heterogeneity of amyloid beta and tau in Alzheimer’s disease through machine learning and transcriptomic integration

Abstract INTRODUCTION Functional brain network alterations associated with Alzheimer’s disease (AD) pathology, including amyloid beta (Aβ) and phosphorylated tau (p-tau), are difficult to interpret due to overlapping aging-associated and non-amyloid biological...