by Clinical Neuropsychologist | Thursday, December 7, 2023 | Dementia
Abstract INTRODUCTION Early-life stress (ES) increases the risk for Alzheimer’s disease (AD). We and others have shown that ES aggravates amyloid-beta (Aβ) pathology and promotes cognitive dysfunction in APP/PS1 mice, but underlying mechanisms remain unclear....
by Clinical Neuropsychologist | Thursday, December 7, 2023 | Dementia
Abstract INTRODUCTION We tested the effect of statins on C-reactive protein (CRP) and apolipoprotein E (APOE)’s associations with dementia severity. METHODS A total of 1725 participants of the Alzheimer’s Disease Neuroimaging Initiative (ADNI) were...
by Clinical Neuropsychologist | Wednesday, December 6, 2023 | Dementia
Abstract INTRODUCTION The number of American Indian and Alaska Native (AI/AN) elders is expected to double by 2060. Thus it is imperative to retain AI/AN participants in longitudinal research studies to identify novel risk factors and potential targets for...
by Clinical Neuropsychologist | Wednesday, December 6, 2023 | Dementia
Abstract INTRODUCTION This study examines how receiving a dementia diagnosis influences social relationships by race and ethnicity. METHODS Using data from the Health and Retirement Study (10 waves; 7,159 observations) of adults 70 years and older predicted to have...
by Clinical Neuropsychologist | Tuesday, December 5, 2023 | Dementia
Abstract INTRODUCTION Variability in relationship of tau-based neurofibrillary tangles (T) and neurodegeneration (N) in Alzheimer’s disease (AD) arises from non-specific nature of N, modulated by non-AD co-pathologies, age-related changes, and resilience...
by Clinical Neuropsychologist | Sunday, December 3, 2023 | Dementia
Abstract The thalamus is a complex neural structure with numerous anatomical subdivisions and intricate connectivity patterns. In recent decades, the traditional view of the thalamus as a relay station and “gateway to the cortex” has expanded in recognition of its...