Early‐life stress and amyloidosis in mice share pathogenic pathways involving synaptic mitochondria and lipid metabolism

by Clinical Neuropsychologist | Thursday, December 7, 2023 | Dementia

Abstract INTRODUCTION Early-life stress (ES) increases the risk for Alzheimer’s disease (AD). We and others have shown that ES aggravates amyloid-beta (Aβ) pathology and promotes cognitive dysfunction in APP/PS1 mice, but underlying mechanisms remain unclear....

Statin use moderates APOE’s and CRP’s associations with dementia and is associated with lesser dementia severity in ε4 carriers

by Clinical Neuropsychologist | Thursday, December 7, 2023 | Dementia

Abstract INTRODUCTION We tested the effect of statins on C-reactive protein (CRP) and apolipoprotein E (APOE)’s associations with dementia severity. METHODS A total of 1725 participants of the Alzheimer’s Disease Neuroimaging Initiative (ADNI) were...

Retention of American Indian and Alaska Native participants in the National Alzheimer’s Coordinating Center Uniform Data Set

by Clinical Neuropsychologist | Wednesday, December 6, 2023 | Dementia

Abstract INTRODUCTION The number of American Indian and Alaska Native (AI/AN) elders is expected to double by 2060. Thus it is imperative to retain AI/AN participants in longitudinal research studies to identify novel risk factors and potential targets for...

An outcome‐wide analysis of the effects of diagnostic labeling of Alzheimer’s disease and related dementias on social relationships

by Clinical Neuropsychologist | Wednesday, December 6, 2023 | Dementia

Abstract INTRODUCTION This study examines how receiving a dementia diagnosis influences social relationships by race and ethnicity. METHODS Using data from the Health and Retirement Study (10 waves; 7,159 observations) of adults 70 years and older predicted to have...

Tau‐neurodegeneration mismatch reveals vulnerability and resilience to comorbidities in Alzheimer’s continuum

by Clinical Neuropsychologist | Tuesday, December 5, 2023 | Dementia

Abstract INTRODUCTION Variability in relationship of tau-based neurofibrillary tangles (T) and neurodegeneration (N) in Alzheimer’s disease (AD) arises from non-specific nature of N, modulated by non-AD co-pathologies, age-related changes, and resilience...

When the central integrator disintegrates: A review of the role of the thalamus in cognition and dementia

by Clinical Neuropsychologist | Sunday, December 3, 2023 | Dementia

Abstract The thalamus is a complex neural structure with numerous anatomical subdivisions and intricate connectivity patterns. In recent decades, the traditional view of the thalamus as a relay station and “gateway to the cortex” has expanded in recognition of its...