Understanding the Experiences of Family Caregivers of Persons Living With Dementia Participating in an ‘Overnight’ Adult Day Program

by Clinical Neuropsychologist Online | Thursday, July 9, 2026 | Dementia

Dementia, Ahead of Print. Family caregivers of persons with dementia often face chronic stress, disrupted sleep, and emotional exhaustion. While adult day programs provide daytime respite, support during nighttime, when caregiving responsibilities can intensify,...

Modular brain networks shape amyloid‐driven tau spread and cognitive decline

by Clinical Neuropsychologist Online | Thursday, July 9, 2026 | Dementia

Abstract INTRODUCTION Alzheimer’s disease involves trans-synaptic spread of tau pathology from temporal lobe epicenters, driven by amyloid beta (Aβ) deposition. How modular brain network architecture shapes this process and the ensuing cognitive decline remains...

Lecanemab treatment improves B cell subpopulation immune homeostasis in patients with Alzheimer’s disease

by Clinical Neuropsychologist Online | Thursday, July 9, 2026 | Dementia

Abstract INTRODUCTION Lecanemab, the first disease-modifying therapy for Alzheimer’s disease (AD), mitigates pathology primarily by clearing amyloid plaques, but its impact on peripheral immunity remains unclear. METHODS To assess Lecanemab’s immunological...

Multicenter validation of plasma p‐tau217/ amyloid beta 1‐42 ratio in symptomatic Alzheimer’s disease

by Clinical Neuropsychologist Online | Thursday, July 9, 2026 | Dementia

Abstract INTRODUCTION This study evaluated the diagnostic performance of the Lumipulse® G pTau 217/β-Amyloid 1-42 Plasma Ratio to detect amyloid positivity in patients with cognitive decline symptoms. METHODS The Lumipulse Plasma Ratio was evaluated using...

Postmortem brain MRI reveals differential associations of subcortical and limbic volumes with cortical thinning and neurodegenerative pathologies

by Clinical Neuropsychologist Online | Thursday, July 9, 2026 | Dementia

Abstract INTRODUCTION The impact of different neuropathologies on deep brain structures remains to be understood. We examine subcortical and limbic volumetry in neurodegenerative diseases involving phosphorylated tau (p-tau), α-synuclein, and transactive response DNA...

Association of sleep duration with Alzheimer’s disease and cognition

by Clinical Neuropsychologist Online | Wednesday, July 8, 2026 | Dementia

Abstract INTRODUCTION The association of sleep duration with Alzheimer’s disease (AD) – related brain atrophy and cognition remains unclear. METHODS Among 38,816 participants in the UK Biobank, we examined the association between sleep duration and a...