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Xenografted human microglia display diverse transcriptomic states in response to Alzheimer’s disease-related amyloid-β pathology

by Clinical Neuropsychologist Online | Wednesday, March 27, 2024 | Neuroscience

Nature Neuroscience, Published online: 27 March 2024; doi:10.1038/s41593-024-01600-yHuman microglia transplanted in the mouse brain mount a multipronged response to amyloid-β pathology, displaying unique transcriptional states. Alzheimer’s disease risk genes are...

TREM1 disrupts myeloid bioenergetics and cognitive function in aging and Alzheimer disease mouse models

by Clinical Neuropsychologist Online | Wednesday, March 27, 2024 | Neuroscience

Nature Neuroscience, Published online: 27 March 2024; doi:10.1038/s41593-024-01610-wThe role of TREM1 in neurodegenerative diseases is unclear. Here the authors show that TREM1 promotes cognitive decline in aging and in the context of amyloid pathology in a mouse...

Long-term in vivo three-photon imaging reveals region-specific differences in healthy and regenerative oligodendrogenesis

by Clinical Neuropsychologist Online | Wednesday, March 27, 2024 | Neuroscience

Nature Neuroscience, Published online: 27 March 2024; doi:10.1038/s41593-024-01613-7Brain region-specific oligodendrocyte population dynamics are unclear. Here the authors implement long-term in vivo three-photon imaging to determine those dynamics in the cortical and...

Ethical considerations for the use of anti‐amyloid immunotherapy in patients with early Alzheimer’s disease

by Clinical Neuropsychologist Online | Tuesday, March 26, 2024 | Dementia

Alzheimer’s &Dementia, EarlyView. If you do not see content above, kindly GO TO SOURCE. Not all publishers encode content in a way that enables republishing at Neuro.vip. This post is Copyright: Susanne J. van Veluw, Michael J. Young | March 26, 2024 Wiley:...

Plasma glial fibrillary acidic protein in the visual and language variants of Alzheimer’s disease

by Clinical Neuropsychologist Online | Tuesday, March 26, 2024 | Dementia

Abstract INTRODUCTION Glial fibrillary acidic protein (GFAP) in plasma is a proxy for astrocytic activity and is elevated in amyloid-β (Aβ)-positive individuals, making GFAP a potential blood-based biomarker for Alzheimer’s disease (AD). METHODS We assessed...
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