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In vivo effect of LATE‐NC on integrity of white matter connections to the hippocampus

by Clinical Neuropsychologist Online | Saturday, June 15, 2024 | Dementia

Abstract INTRODUCTION TAR DNA-binding protein 43 (TDP-43) is a highly prevalent proteinopathy that is involved in neurodegenerative processes, including axonal damage. To date, no ante mortem biomarkers exist for TDP-43, and few studies have directly assessed its...

Unlocking the potential of ‘passive’ modulation: How sensory stimulation shapes hand and face size

by Clinical Neuropsychologist Online | Saturday, June 15, 2024 | Neuropsychology (general)

Abstract Knowledge of the body size is intricately tied to multisensory integration processes that rely on the dynamic interplay of top-down and bottom-up mechanisms. Recent years have seen the development of passive sensory stimulation protocols aimed at...

Patterns of cognitive domain abnormalities enhance discrimination of dementia risk prediction: The ARIC study

by Clinical Neuropsychologist Online | Saturday, June 15, 2024 | Dementia

Abstract INTRODUCTION The contribution of neuropsychological assessments to risk assessment for incident dementia is underappreciated. METHODS We analyzed neuropsychological testing results in dementia-free participants in the Atherosclerosis Risk in Communities...

Mild behavioral impairment domains are longitudinally associated with pTAU and metabolic biomarkers in dementia‐free older adults

by Clinical Neuropsychologist Online | Saturday, June 15, 2024 | Dementia

Abstract BACKGROUND The mechanisms linking mild behavioral impairment (MBI) and Alzheimer’s disease (AD) have been insufficiently explored, with conflicting results regarding tau protein and few data on other metabolic markers. We aimed to evaluate the...

Entorhinal vessel density correlates with phosphorylated tau and TDP‐43 pathology

by Clinical Neuropsychologist Online | Saturday, June 15, 2024 | Dementia

Abstract INTRODUCTION The entorhinal cortex (EC) and perirhinal cortex (PC) are vulnerable to Alzheimer’s disease. A triggering factor may be the interaction of vascular dysfunction and tau pathology. METHODS We imaged post mortem human tissue at 100 μm3 with 7...
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