by Clinical Neuropsychologist Online | Tuesday, June 11, 2024 | Dementia
Abstract INTRODUCTION Female-specific reproductive factors and exogeneous estrogen use are associated with cognition in later life. However, the underlying mechanisms are not understood. The present study aimed to investigate the effect of reproductive factors on...
by Clinical Neuropsychologist Online | Tuesday, June 11, 2024 | Dementia
Abstract INTRODUCTION Most people with Alzheimer’s disease and related dementia (ADRD) also suffer from two or more chronic conditions, known as multiple chronic conditions (MCC). While many studies have investigated the MCC patterns, few studies have considered...
by Clinical Neuropsychologist Online | Tuesday, June 11, 2024 | Neuroscience
Nature Neuroscience, Published online: 11 June 2024; doi:10.1038/s41593-024-01680-wThe mechanisms regulating microglial response to brain injury are unclear. Here, the authors show that astrocytic ATP dynamics encode injury information and trigger microglia response...
by Clinical Neuropsychologist Online | Monday, June 10, 2024 | Dementia
Abstract INTRODUCTION The ɛ4 allele of the apolipoprotein E gene (APOE ɛ4) is the strongest genetic risk factor for Alzheimer’s disease (AD), but the mechanisms connecting APOE ɛ4 to AD are not clear. METHODS Participants (n = 596) were from two...
by Clinical Neuropsychologist Online | Monday, June 10, 2024 | Neuroscience
Nature Neuroscience, Published online: 10 June 2024; doi:10.1038/s41593-024-01679-3The thalamus is important for neocortical functional specialization. Here the authors show its shifting role in shaping large-scale functional organization during early life in humans,...
