by Clinical Neuropsychologist Online | Saturday, July 20, 2024 | Dementia
Abstract INTRODUCTION The immune receptor triggering receptor expressed on myeloid cells 2 (TREM2) is among the strongest genetic risk factors for Alzheimer’s disease (AD) and is a therapeutic target. TREM2 multimers have been identified in crystallography and...
by Clinical Neuropsychologist Online | Saturday, July 20, 2024 | Dementia
Abstract INTRODUCTION We examined whether baseline glial markers soluble triggering receptor expressed on myeloid cell 2 (sTREM2), chitinase 3-like protein 1 (YKL-40), and glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF), and plasma GFAP are...
by Clinical Neuropsychologist Online | Saturday, July 20, 2024 | Dementia
Abstract INTRODUCTION The apolipoprotein E gene (APOE) is an established central player in the pathogenesis of Alzheimer’s disease (AD), with distinct apoE isoforms exerting diverse effects. apoE influences not only amyloid-beta and tau pathologies but also...
by Clinical Neuropsychologist Online | Friday, July 19, 2024 | Dementia
Abstract INTRODUCTION We aimed to evaluate clinical interpretation cutpoints for two plasma phosphorylated tau (p-tau)217 assays (ALZpath and Lumipulse) as predictors of amyloid status for implementation in clinical practice. METHODS Clinical performance of plasma...
by Clinical Neuropsychologist Online | Friday, July 19, 2024 | Neuroscience
Nature Neuroscience, Published online: 19 July 2024; doi:10.1038/s41593-024-01703-6Liu et al. unraveled several hippocampal neural ensemble coding schemes that efficiently represent numerous daily experiences during sleep by prioritizing the most recent and earliest...
