by Clinical Neuropsychologist Online | Wednesday, July 17, 2024 | Neuro Podcasts
In the latest Naked Neuroscience, James Tytko brings you two new pieces of research involving the use of AI. First, how machine learning has been deployed to map out the visual system of a fruit fly in all its complexity, and how feeding a neural network a diet of...
by Clinical Neuropsychologist Online | Wednesday, July 17, 2024 | Dementia
Abstract INTRODUCTION Consensus definitions of meaningful within-patient change (MWPC) on the Clinical Dementia Rating-Sum of Boxes (CDR-SB) are needed. Existing estimates use clinician-rated anchors in clinically diagnosed Alzheimer’s disease (AD) populations....
by Clinical Neuropsychologist Online | Wednesday, July 17, 2024 | Dementia
Abstract INTRODUCTION Aging is one of the risk factors for the early onset of Alzheimer’s disease (AD). We previously discovered that the age-dependent increase in Ubiquitin Conjugating Enzyme E2 N (UBE2N) plays a role in the accumulation of misfolded proteins...
by Clinical Neuropsychologist Online | Wednesday, July 17, 2024 | Neuroscience
Nature Neuroscience, Published online: 17 July 2024; doi:10.1038/s41593-024-01714-3Perineuronal nets stabilize synapses inhibiting synaptic plasticity. Here, the authors show that perineuronal nets act as a diffusion barrier facilitating astrocytic clearance of...
by Clinical Neuropsychologist Online | Tuesday, July 16, 2024 | Dementia
Abstract Extracellular vesicles (EVs) hold promise as a source of disease biomarkers. The diverse molecular cargo of EVs can potentially indicate the status of their tissue of origin, even against the complex background of whole plasma. The main tools currently...
