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The memory binding test in a longitudinal study of cognitive aging and preclinical disease.

by Clinical Neuropsychologist Online | Monday, July 8, 2024 | Neuropsychology (general)

Neuropsychology, Vol 38(6), Sep 2024, 570-588; doi:10.1037/neu0000952Objective: The Memory Binding Test (MBT) shows promise in detecting early cognitive changes associated with Alzheimer’s disease (AD). This study assesses the psychometric properties (i.e., construct...

A vagal–brainstem interoceptive circuit for cough-like defensive behaviors in mice

by Clinical Neuropsychologist Online | Monday, July 8, 2024 | Neuroscience

Nature Neuroscience, Published online: 08 July 2024; doi:10.1038/s41593-024-01712-5Gannot et al. show that Tac1 neurons in the NTS mediate an airway–vagal–brain pathway that is crucial for coughing in mice. These neurons receive direct vagal sensory inputs and...

Microglia are dispensable for experience-dependent refinement of mouse visual circuitry

by Clinical Neuropsychologist Online | Monday, July 8, 2024 | Neuroscience

Nature Neuroscience, Published online: 08 July 2024; doi:10.1038/s41593-024-01706-3The authors test the model that microglia are crucial for the developmental refinement of neural circuitry by depleting them with PLX5622. Microglia prove dispensable for the...

Caregiver coping mediates the relationship between caregivers’ understanding of dementia as terminal and their distress

by Clinical Neuropsychologist Online | Sunday, July 7, 2024 | Dementia

Abstract We assessed which coping strategies (problem-focused, emotion-focused, dysfunctional) mediate the association between caregivers’ understanding of dementia as terminal and their distress. A total of 215 caregivers of community-dwelling persons with severe...

CSF proteomic profiles of neurodegeneration biomarkers in Alzheimer’s disease

by Clinical Neuropsychologist Online | Saturday, July 6, 2024 | Dementia

Abstract INTRODUCTION We aimed to unravel the underlying pathophysiology of the neurodegeneration (N) markers neurogranin (Ng), neurofilament light (NfL), and hippocampal volume (HCV), in Alzheimer’s disease (AD) using cerebrospinal fluid (CSF) proteomics....
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