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Deletion of miR‐33, a regulator of the ABCA1–APOE pathway, ameliorates neuropathological phenotypes in APP/PS1 mice

by Clinical Neuropsychologist Online | Monday, September 30, 2024 | Dementia

Abstract INTRODUCTION Rare variants in ABCA1 increase the risk of developing Alzheimer’s disease (AD). ABCA1 facilitates the lipidation of apolipoprotein E (apoE). This study investigated whether microRNA-33 (miR-33)-mediated regulation of this ABCA1–APOE...

Rapid instructed task learning is impaired after stroke and associated with impairments in prepotent inhibition and processing speed.

by Clinical Neuropsychologist Online | Monday, September 30, 2024 | Neuropsychology (general)

Neuropsychology, Vol 39(1), Jan 2025, 65-75; doi:10.1037/neu0000979Objective: Motor rehabilitation is a central contributor to motor recovery after stroke. Rehabilitation could be hampered by stroke-associated cognitive impairments such as the decreased ability to...

Electrophysiological evidence of nonspatial inhibition of return affecting audiovisual integration.

by Clinical Neuropsychologist Online | Monday, September 30, 2024 | Neuropsychology (general)

Neuropsychology, Vol 39(1), Jan 2025, 76-88; doi:10.1037/neu0000976Objective: The present study endeavored to investigate the potential neural underpinnings of disparities in audiovisual integration (AVI) between valid and invalid targets, modulated by nonspatial...

Stimulating Wnt signaling reveals context-dependent genetic effects on gene regulation in primary human neural progenitors

by Clinical Neuropsychologist Online | Monday, September 30, 2024 | Neuroscience

Nature Neuroscience, Published online: 30 September 2024; doi:10.1038/s41593-024-01773-6Matoba, Le, Valone et al. characterized context-dependent genetic effects on gene regulatory activity during Wnt stimulation, finding that genetic variant function during...

Proinflammatory immune cells disrupt angiogenesis and promote germinal matrix hemorrhage in prenatal human brain

by Clinical Neuropsychologist Online | Monday, September 30, 2024 | Neuroscience

Nature Neuroscience, Published online: 30 September 2024; doi:10.1038/s41593-024-01769-2Chen et al. show that subtypes of immune cells in prenatal human brain promote angiogenesis in the germinal matrix. Conversely, in preterm infants, proinflammatory immune cells...
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