by Clinical Neuropsychologist Online | Thursday, September 12, 2024 | Dementia
Abstract INTRODUCTION The molecular basis of cognitive resilience (CR) among pathologically confirmed Alzheimer’s disease (AD) cases is not well understood. METHODS Abundance of 13 cell types and neuronal subtypes in brain bulk RNA-seq data from the anterior...
by Clinical Neuropsychologist Online | Thursday, September 12, 2024 | Dementia
Abstract INTRODUCTION Regional glucose hypometabolism resulting in glutamate loss has been shown as one of the characteristics of Alzheimer’s disease (AD). Because the impact of AD varies between the sexes, we utilized glutamate-weighted chemical exchange...
by Clinical Neuropsychologist Online | Thursday, September 12, 2024 | Neuroscience
Nature Neuroscience, Published online: 12 September 2024; doi:10.1038/s41593-024-01750-zWe reveal that lipid turnover in the myelin sheath generates a fatty acid pool in oligodendrocytes that can contribute to the energy balance of white matter tracts. We also...
by Clinical Neuropsychologist Online | Thursday, September 12, 2024 | Neuroscience
Nature Neuroscience, Published online: 12 September 2024; doi:10.1038/s41593-024-01754-9The mechanisms underlying the ability to remyelinate in aging and disease are unclear. Here, the authors show that DOR-mediated activation of α-ketoglutarate in mature...
by Clinical Neuropsychologist Online | Thursday, September 12, 2024 | Neuroscience
The neural mechanisms of motor planning have been extensively studied in rodents. Preparatory activity in the frontal cortex predicts upcoming choice, but limitations of typical tasks have made it challenging to determine whether the spatial information is in a...
