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Single-nucleus transcriptomic profiling of human orbitofrontal cortex reveals convergent effects of aging and psychiatric disease

by Clinical Neuropsychologist Online | Tuesday, September 3, 2024 | Neuroscience

Nature Neuroscience, Published online: 03 September 2024; doi:10.1038/s41593-024-01742-zSingle-cell profiling in the human cortex reveals aging-associated transcriptomic changes across all brain cell types, which overlap with effects with Alzheimer’s disease and show...

Inhibitory plasticity supports replay generalization in the hippocampus

by Clinical Neuropsychologist Online | Tuesday, September 3, 2024 | Neuroscience

Nature Neuroscience, Published online: 03 September 2024; doi:10.1038/s41593-024-01745-wThe study of neural plasticity has focused on excitatory neural connections, but inhibitory connections can also change. Learning at inhibitory synapses may support high-level...

Laterality in tactile working memory: The one‐hand version of the Tactual Span

by Clinical Neuropsychologist Online | Monday, September 2, 2024 | Neuropsychology (general)

Abstract The Tactual Span assesses tactile working memory (WM) using both hands while applying forward and backward conditions. The study objectives were to validate a one-hand version of the Tactual Span and to evaluate WM laterality in the tactile modality. Of the...

Utility of cerebrovascular imaging biomarkers to detect cerebral amyloidosis

by Clinical Neuropsychologist Online | Monday, September 2, 2024 | Dementia

Abstract INTRODUCTION The relationship between cerebrovascular disease (CVD) and amyloid beta (Aβ) in Alzheimer’s disease (AD) is understudied. We hypothesized that magnetic resonance imaging (MRI)–based CVD biomarkers—including cerebral microbleeds (CMBs),...

The ADNI4 Digital Study: A novel approach to recruitment, screening, and assessment of participants for AD clinical research

by Clinical Neuropsychologist Online | Monday, September 2, 2024 | Dementia

Abstract INTRODUCTION We evaluated preliminary feasibility of a digital, culturally-informed approach to recruit and screen participants for the Alzheimer’s Disease Neuroimaging Initiative (ADNI4). METHODS Participants were recruited using digital advertising...
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