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Inhibition of IFITM3 in cerebrovascular endothelium alleviates Alzheimer’s‐related phenotypes

by Clinical Neuropsychologist Online | Tuesday, January 14, 2025 | Dementia

Abstract INTRODUCTION Interferon-induced transmembrane protein 3 (IFITM3) modulates γ-secretase in Alzheimer’s Disease (AD). Although IFITM3 knockout reduces amyloid β protein (Aβ) production, its cell-specific effect on AD remains unclear. METHODS Single...

Transcranial Doppler Arterial Pressure Gradient Is Associated With Delayed Infarction After Subarachnoid Hemorrhage

by Clinical Neuropsychologist Online | Monday, January 13, 2025 | Neuroimaging

ABSTRACT Background and Purpose While the pulsatility index (PI) measured by transcranial Doppler (TCD) has broader associations with outcomes in neurocritical care, its use in monitoring delayed cerebral infarction (DCI) in patients with aneurysmal subarachnoid...

Poststroke Translocator Protein Expression Dynamics and Correlations to Chronic Infarction: A [123I]‐CLINDE‐SPECT Study

by Clinical Neuropsychologist Online | Monday, January 13, 2025 | Neuroimaging

ABSTRACT Background and Purpose This study aims to investigate the longitudinal changes in translocator protein (TSPO) following stroke in different brain regions and potential associations with chronic brain infarction. Methods Twelve patients underwent SPECT using...

Distal Access Catheter Improves Balloon Guide and Stent Retriever Thrombectomy Outcomes in Nonagenarians

by Clinical Neuropsychologist Online | Monday, January 13, 2025 | Neuroimaging

ABSTRACT Background and Purpose The safety and effectiveness of endovascular techniques in elderly patients with large vessel occlusion (LVO) remain controversial. We investigated the angiographic and clinical outcomes of nonagenarians treated with different...

Utilizing Quantitative Analysis of CSF Volume from Clinical T1‐Weighted MRI to Predict Thrombectomy Outcomes

by Clinical Neuropsychologist Online | Monday, January 13, 2025 | Neuroimaging

ABSTRACT Background and Purpose Endovascular thrombectomy (EVT) is the standard for acute ischemic stroke from large vessel occlusion, but post-EVT functional independence varies. Brain atrophy, linked to higher cerebrospinal fluid volume (CSFV), may affect outcomes....
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