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Vascular risk factors and cerebrovascular pathologic changes on autopsy: The 90+ Study

by Clinical Neuropsychologist Online | Tuesday, January 7, 2025 | Dementia

Abstract INTRODUCTION Cerebrovascular pathologic changes (CVPC) are prevalent and associated with dementia in those ≥ 90 years. However, CVPC associations to traditional risk factors (hypertension, diabetes, and hyperlipidemia) are variable. We hypothesized that...

Alzheimer’s Disease Neuroimaging Initiative: Two decades of pioneering Alzheimer’s disease research and future directions

by Clinical Neuropsychologist Online | Monday, January 6, 2025 | Dementia

Alzheimer’s &Dementia, EarlyView. If you do not see content above, kindly GO TO SOURCE. Not all publishers encode content in a way that enables republishing at Neuro.vip. This post is Copyright: Ozioma C. Okonkwo, Monica Rivera‐Mindt, Michael W. Weiner, for...

Middle Cerebral Artery M2 Occlusions: Impact of Segment Dominance and Benefit of Direct Aspiration for the First‐Pass Effect

by Clinical Neuropsychologist Online | Monday, January 6, 2025 | Neuroimaging

ABSTRACT Background and Purpose Endovascular thrombectomy (EVT) for acute ischemic stroke (AIS) with M2 segment occlusion of the middle cerebral artery (MCA) is debatable. This study assessed the efficacy, safety, and functional outcomes of EVT in M2 occlusion...

Functional Connectivity to the Amygdala in the Neonate Is Impacted by the Maternal Anxiety Level During Pregnancy

by Clinical Neuropsychologist Online | Monday, January 6, 2025 | Neuroimaging

ABSTRACT Background and Purpose Anxiety during pregnancy is common, and exposure to heightened anxiety during pregnancy may influence children’s brain development and functioning. However, it is unclear if exposure to low levels of anxiety in utero would also...

Multimodal transcriptomics reveal neurogenic aging trajectories and age-related regional inflammation in the dentate gyrus

by Clinical Neuropsychologist Online | Monday, January 6, 2025 | Neuroscience

Nature Neuroscience, Published online: 06 January 2025; doi:10.1038/s41593-024-01848-4Multimodal transcriptomics unveil the molecular dynamics of neural stem cells and their surrounding niche in the aging mouse hippocampus and provide a resource to understand...
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