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Neural populations are dynamic but constrained

by Clinical Neuropsychologist Online | Friday, January 17, 2025 | Neuroscience

Nature Neuroscience, Published online: 17 January 2025; doi:10.1038/s41593-024-01793-2Our brains evolved to help us rapidly learn new things. But anyone who has put in hours of practice to perfect their tennis serve, only to reach a plateau, can attest that our brains...

Propagation of neuronal micronuclei regulates microglial characteristics

by Clinical Neuropsychologist Online | Friday, January 17, 2025 | Neuroscience

Nature Neuroscience, Published online: 17 January 2025; doi:10.1038/s41593-024-01863-5Neuronal micronuclei are transferred to microglia during the early postnatal period, which leads to altered microglial morphology and transcriptomic signatures, suggesting that these...

Dynamical constraints on neural population activity

by Clinical Neuropsychologist Online | Friday, January 17, 2025 | Neuroscience

Nature Neuroscience, Published online: 17 January 2025; doi:10.1038/s41593-024-01845-7Oby, Degenhart, Grigsby and colleagues used a brain–computer interface to challenge monkeys to override their natural time courses of neural activity. They found the time courses to...

High‐Field‐Blinded Assessment of Portable Ultra‐Low‐Field Brain MRI for Multiple Sclerosis

by Clinical Neuropsychologist Online | Thursday, January 16, 2025 | Neuroimaging

ABSTRACT Background and Purpose MRI is crucial for multiple sclerosis (MS), but the relative value of portable ultra-low field MRI (pULF-MRI), a technology that holds promise for extending access to MRI, is unknown. We assessed white matter lesion (WML) detection on...

Predicting Alzheimer’s disease subtypes and understanding their molecular characteristics in living patients with transcriptomic trajectory profiling

by Clinical Neuropsychologist Online | Wednesday, January 15, 2025 | Dementia

Abstract INTRODUCTION Deciphering the diverse molecular mechanisms in living Alzheimer’s disease (AD) patients is a big challenge but is pivotal for disease prognosis and precision medicine development. METHODS Utilizing an optimal transport approach, we...
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