The tau isoform 1N4R confers vulnerability of MAPT knockout human iPSC‐derived neurons to amyloid beta and phosphorylated tau‐induced neuronal dysfunction

by | Friday, February 28, 2025 | Dementia

Abstract INTRODUCTION Human tau protein, composed of six brain-specific isoforms, is a major driver of Alzheimer’s disease (AD). The role of its isoforms however remains unclear and human AD models are scarce. METHODS We generated human MAPT– (tau–) knockout...

495. Head, Heart, Hiring

by | Thursday, February 27, 2025 | Neuro Podcasts

Would you rather read the transcript? Click here. Today we’re diving into one of the biggest decisions private practice owners face: when to hire help. If you’ve ever found yourself drowning in scheduling, billing, or intake calls, or if your waitlist is stretching...

Nasal anti-CD3 monoclonal antibody ameliorates traumatic brain injury, enhances microglial phagocytosis and reduces neuroinflammation via IL-10-dependent Treg–microglia crosstalk

by | Thursday, February 27, 2025 | Neuroscience

Nature Neuroscience, Published online: 27 February 2025; doi:10.1038/s41593-025-01877-7Nasal anti-CD3 therapy shows promise for treating traumatic brain injury by reducing neuroinflammation and aiding recovery in mice. It induces interleukin-10-producing regulatory T...