by Clinical Neuropsychologist Online | Wednesday, February 19, 2025 | Dementia
Abstract INTRODUCTION We examined how abnormal prefrontal neurophysiology and changes in gamma-aminobutyric acid-ergic (GABAergic) neurotransmission contribute to behavioral impairments in disorders associated with frontotemporal lobar degeneration (FTLD). METHODS We...
by Clinical Neuropsychologist Online | Wednesday, February 19, 2025 | Dementia
Abstract INTRODUCTION Early-onset and late-onset Alzheimer’s disease (EOAD and LOAD, respectively) have distinct clinical manifestations, with prior work based on small samples suggesting unique patterns of neurodegeneration. The current study performed a...
by Clinical Neuropsychologist Online | Wednesday, February 19, 2025 | Dementia
Abstract INTRODUCTION To study the relationship of late-life hemoglobin A1C (A1C) with postmortem neuropathology in older adults with and without diabetes mellitus (DM). METHODS A total of 990 participants from five cohort studies of aging and dementia with at least...
by Clinical Neuropsychologist Online | Wednesday, February 19, 2025 | Neuroimaging
ABSTRACT Background and Purpose Primary trigeminal neuralgia (PTN) is a prevalent chronic pain disorder whose pathogenesis is not solely confined to the trigeminal system. Although substantial progress has been made in understanding the underlying mechanisms,...
by Clinical Neuropsychologist Online | Wednesday, February 19, 2025 | Neuroscience
Nature Neuroscience, Published online: 19 February 2025; doi:10.1038/s41593-025-01890-wThrough circuit dissection in juvenile, adolescent and adult mice, Klune, Goodpaster and colleagues reveal multiple developmental switches in mPFC–NAc and mPFC–BLA pathways that...
