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Cladribine Is Associated With Stable Cortical Gray Matter Lesion Burden in Multiple Sclerosis: A 7T MRI Study

by Clinical Neuropsychologist Online | Wednesday, March 19, 2025 | Neuroimaging

ABSTRACT Background and Purpose Cladribine, an FDA-approved disease-modifying immunotherapy for multiple sclerosis (MS), penetrates the CSF and mitigates T cells and B cells, and thus may impact the development of cortical gray matter lesions (CLs) and leptomeningeal...

Composing hippocampal maps from cortical building blocks in replay

by Clinical Neuropsychologist Online | Tuesday, March 18, 2025 | Neuroscience

Nature Neuroscience, Published online: 18 March 2025; doi:10.1038/s41593-025-01909-2We modeled how the hippocampus can construct new cognitive maps from reusable building blocks (structural elements) represented in cortex. This composition supported latent learning...

Lewy body disease can spread via two distinct body-first routes

by Clinical Neuropsychologist Online | Tuesday, March 18, 2025 | Neuroscience

Nature Neuroscience, Published online: 18 March 2025; doi:10.1038/s41593-025-01911-8Lewy body disease (LBD) pathology can first spread from the brain or the body. A study of two large postmortem datasets reveals that there are not one but two possible trajectories...

Prospective contingency explains behavior and dopamine signals during associative learning

by Clinical Neuropsychologist Online | Tuesday, March 18, 2025 | Neuroscience

Nature Neuroscience, Published online: 18 March 2025; doi:10.1038/s41593-025-01915-4The authors show that behavior and dopamine responses track prospective, but not retrospective, contingency. These results are explained by temporal difference (TD) learning models,...

499. Ecological Assessment: VR and Holistic Approaches

by Clinical Neuropsychologist Online | Monday, March 17, 2025 | Neuro Podcasts

Would you rather read the transcript? Click here. Today we’re diving into one of the most exciting and rapidly evolving areas of psychological assessment—Virtual Reality (VR) and Holistic Assessment. Traditional assessments are incredibly valuable, but they often have...
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