by Clinical Neuropsychologist Online | Wednesday, March 26, 2025 | Neuroimaging
ABSTRACT Background and Purpose 99mTc-TRODAT-1 SPECT imaging is an imaging technique, more commonly used in Asia, to diagnose Parkinson’s disease (PD). This study evaluates the use of automated three-dimensional volume-of-interest (VOI) analysis in diagnosing...
by Clinical Neuropsychologist Online | Wednesday, March 26, 2025 | Dementia
Abstract INTRODUCTION Plasma phosphorylated threonine 181 of tau (pTau181) and amyloid beta (Aβ) are biomarkers for differential diagnosis and preclinical detection of Alzheimer disease (AD). Given differences in AD risk across diverse populations,...
by Clinical Neuropsychologist Online | Wednesday, March 26, 2025 | Dementia
Abstract INTRODUCTION Distinguishing between molecular changes that precede dementia onset and those resulting from the disease is challenging with cross-sectional studies. METHODS We studied blood DNA methylation (DNAm) differences and incident dementia in two large...
by Clinical Neuropsychologist Online | Wednesday, March 26, 2025 | Dementia
Abstract INTRODUCTION We aimed to determine whether cognitively unimpaired (CU) amyloid- beta-positive (Aβ+) individuals display decreased practice effects on serial neuropsychological testing. METHODS We included 209 CU participants from three research centers, 157...
by Clinical Neuropsychologist Online | Wednesday, March 26, 2025 | Dementia
Abstract INTRODUCTION Disturbances in microvascular flow dynamics are hypothesized to precede the symptomatic phase of Alzheimer’s disease (AD). However, evidence in presymptomatic AD remains elusive, underscoring the need for therapies targeting these early...
