by Clinical Neuropsychologist Online | Monday, April 7, 2025 | Dementia
Abstract INTRODUCTION Numerous studies on Alzheimer’s disease polygenic risk scores (PRSs) overlook sample overlap between International Genomics of Alzheimer’s Project (IGAP) and target datasets like Alzheimer’s Disease Neuroimaging Initiative...
by Clinical Neuropsychologist Online | Monday, April 7, 2025 | Dementia
Abstract INTRODUCTION The entorhinal cortex (ERC) and perforant path (PP) fibers are critical structures in the pathology of Alzheimer’s disease (AD). This study aims to explore these regions using high-field magnetic resonance imaging (MRI), with the goal of...
by Clinical Neuropsychologist Online | Monday, April 7, 2025 | Dementia
Abstract INTRODUCTION Neighborhood-level socioeconomic status (nSES) is associated with risk for cognitive impairment, but prior studies assessed nSES within an individual’s own residential area without considering the distribution of nSES among adjacent areas....
by Clinical Neuropsychologist Online | Monday, April 7, 2025 | Dementia
Abstract BACKGROUND Adults with Down syndrome (DS) have increased risk of Alzheimer’s disease (AD). The cholinergic system declines in AD, underlying many cognitive deficits. We investigated the relationship between amyloid accumulation and cholinergic terminal...
by Clinical Neuropsychologist Online | Monday, April 7, 2025 | Neuroscience
Nature Neuroscience, Published online: 07 April 2025; doi:10.1038/s41593-025-01931-4Microglia have key roles in CNS development and neurodegeneration. Here, the authors provide an overview of microglia heterogeneity, cell-state annotation and model systems. If you do...
