by Clinical Neuropsychologist Online | Tuesday, October 21, 2025 | Neuropsychology (general)
Abstract The serial position effect is a well-established phenomenon characterised by better recall of items at the beginning and end of a list compared to those in the middle. A reduced primacy effect—reflected by diminished recall of items from the initial...
by Clinical Neuropsychologist Online | Tuesday, October 21, 2025 | Neuropsychology (general)
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by Clinical Neuropsychologist Online | Tuesday, October 21, 2025 | Neuroscience
Nature Neuroscience, Published online: 21 October 2025; doi:10.1038/s41593-025-02065-3In amyotrophic lateral sclerosis (ALS), nuclear depletion and cytoplasmic aggregation of the RNA-binding protein TDP-43 cause widespread dysregulation of mRNA splicing. Two recent...
by Clinical Neuropsychologist Online | Tuesday, October 21, 2025 | Neuroscience
Nature Neuroscience, Published online: 21 October 2025; doi:10.1038/s41593-025-02050-wThe authors find that TDP-43 loss of function—the pathology defining the neurodegenerative conditions ALS and FTD—induces novel mRNA polyadenylation events, which have different...
by Clinical Neuropsychologist Online | Tuesday, October 21, 2025 | Neuroscience
Nature Neuroscience, Published online: 21 October 2025; doi:10.1038/s41593-025-02049-3Zeng et al. show that TDP-43, known for repressing cryptic exon usage in frontotemporal dementia/amyotrophic lateral sclerosis, also controls alternative polyadenylation, impacting...
