by Clinical Neuropsychologist Online | Thursday, September 24, 2026 | Dementia
Abstract INTRODUCTION Aspirin is not recommended for dementia prevention due to limited benefit. We investigated whether genetic subgroups may benefit. METHODS In the ASPirin in Reducing Events in the Elderly (ASPREE) trial (n = 13,541), we screened 5182 polygenic...
by Clinical Neuropsychologist Online | Thursday, September 24, 2026 | Dementia
Abstract INTRODUCTION The adiposity–cognition relationship in aging is controversial. This study aimed to assess its sex- and age-specific associations with Alzheimer’s disease (AD) pathology using multimodal biomarkers. METHODS In two longitudinal cohorts (Hubei...
by Clinical Neuropsychologist Online | Thursday, September 24, 2026 | Dementia
Abstract INTRODUCTION Cognitive changes in the asymptomatic stages of Alzheimer disease (AD) are subtle and difficult to detect using conventional cognitive tests. High-frequency smartphone-based testing may improve sensitivity to these changes, but generational...
by Clinical Neuropsychologist Online | Thursday, September 24, 2026 | Dementia
Abstract INTRODUCTION Microglia-mediated clearance of amyloid beta (Aβ) is crucial for mitigating Alzheimer’s disease (AD) progression, yet the molecular regulators of microglial phagocytosis remain incompletely understood. METHODS We assessed AD-related...
by Clinical Neuropsychologist Online | Thursday, September 24, 2026 | Dementia
Dementia, Ahead of Print. The use of digital tools in reminiscence interventions has increased in recent years, encompassing multimedia platforms, virtual reality (VR), digital life storybooks, and interactive applications. Yet, evidence regarding the effectiveness of...
