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Modality-specific reactive and predictive responses in the human superior colliculus

by Clinical Neuropsychologist Online | Wednesday, October 7, 2026 | Neuroscience

Nature Neuroscience, Published online: 07 October 2026; doi:10.1038/s41593-026-02480-0Chen et al. use 7-Tesla fMRI to show that the human superior colliculus has modality-specific, depth-dependent activity prior to visual or somatosensory events, resembling its...

Astrocytes regulate axonal mitochondrial transport deficits in C9ORF72 amyotrophic lateral sclerosis motor neurons

by Clinical Neuropsychologist Online | Wednesday, October 7, 2026 | Neuroscience

Nature Neuroscience, Published online: 07 October 2026; doi:10.1038/s41593-026-02464-0Astrocytes regulate axonal mitochondrial transport in motor neurons through mitochondrial bioenergetics, a process disrupted in C9ORF72-mediated amyotrophic lateral sclerosis....

Cognitive impairment in Parkinson disease correlates with loss of cholinergic axon projections to cortex in an autopsy study

by Clinical Neuropsychologist Online | Tuesday, October 6, 2026 | Dementia

Abstract INTRODUCTION People with Parkinson’s disease (PD) frequently develop dementia. We investigated the relationship between cognitive impairment and the loss of cholinergic axon projections from the nucleus basalis of Meynert to neocortical regions in PD....

A murine model of amyloid enhanced tauopathy: progressive changes in tau pathology and behavior

by Clinical Neuropsychologist Online | Tuesday, October 6, 2026 | Dementia

Abstract BACKGROUND Our prior work demonstrated systemic P301L-tau injections in mice with mature amyloid resulted in several-fold enhancement of tauopathy compared to non-transgenic (NTg) littermates. METHODS APP+PS1 mice were injected intravenously with AAV.CAP-B10...

Longitudinal untargeted metabolomics of cognitive impairment in Parkinson’s disease

by Clinical Neuropsychologist Online | Tuesday, October 6, 2026 | Dementia

Abstract INTRODUCTION Cognitive impairment is a common non-motor symptom of Parkinson’s disease (PD), yet the mechanism remains unclear. METHODS Longitudinal serum samples from PD patients in a community-based case–control study were profiled, with cognition...
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