Nature Neuroscience, Published online: 12 August 2025; doi:10.1038/s41593-025-02029-7Human-specialized features of immature dentate granule cells (imGCs) formed during adult hippocampal neurogenesis are poorly characterized. Using machine learning-augmented analysis of single-cell RNA-sequencing data, we have revealed human-specific gene expression but convergent biological processes for imGCs across mammalian species. We further demonstrated functional roles of human imGC-enriched proton-transporting ATPase subtypes in neuronal development.
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This post is Copyright: | August 12, 2025
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