Nature Neuroscience, Published online: 24 November 2025; doi:10.1038/s41593-025-02140-9Syntaxin-1A, a SNARE protein mediating membrane fusion for neurotransmission, forms clusters with unclear functions. Using light-controlled clustering, the authors found that phase-separation-driven clusters, regulated by Munc18, suppress fusion, revealing a new phase-separation-based mechanism.
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This post is Copyright: | November 24, 2025
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