Nature Neuroscience, Published online: 20 May 2026; doi:10.1038/s41593-026-02299-9Tau aggregates disrupt heterochromatin by sequestering H3K9me3, reactivating transposable elements. This generates Z-RNAs, activating ZBP1 to drive neuronal death. ZBP1 haploinsufficiency reverses cognitive decline in aged tau mice, offering a therapeutic target for tauopathies.
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This post is Copyright: | May 20, 2026
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