Abstract
INTRODUCTION
Longitudinal studies linking sedentary behavior (SB) in different contexts to brain structure and white matter hyperintensity (WMH) volume remain limited.
METHODS
We analyzed data from the Atherosclerosis Risk in Communities (ARIC) study (n = 1,712). Self-reported SB was assessed at visit 1 (1987–1989), with neuroimaging (3T magnetic resonance imaging [MRI]) at visit 5 (2011–2013). Participants were non-demented adults (57% women; 53[5.2] years) who reported frequency of TV watching and occupational sitting. Outcomes included cortical, subcortical, and Alzheimer’s disease–signature regions (ADSR), and total WMH brain volumes.
RESULTS
Frequent TV watching was associated with increased WMH volume and reduced frontal, occipital, and ADSR volumes. Sitting during work, which is more cognitively active, was linked to lower WMH and larger frontal (males only), occipital, and parietal volumes. Results remained consistent when adjusted for physical activity.
DISCUSSION
SB is associated with structural brain and WMH volumes. Cognitively active SB may preserve brain structure and cerebrovascular health.
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This post is Copyright: | July 10, 2026
Neuro-Dementia