Abstract
INTRODUCTION
Data are needed to inform best practices for disclosing apolipoprotein E (APOE) results given increasing indications for testing.
METHODS
CONNECT4, a multi-center, randomized trial (NCT02978729) compared disclosure of APOE genotype by videoconference or telephone among cognitively unimpaired adults 60–75 years of age. Outcomes were collected at baseline, 2–7 days, 6 weeks, and 6 months.
RESULTS
A total of 301 participants were randomized to telephone and 297 to videoconference disclosure. There were no significant differences between arms for primary or secondary patient-reported outcomes. Moderator analyses found that videoconference reduced depressive symptoms more for older participants (70–75 year), whereas teleconference reduced depressive symptoms more for younger participants (60–64 years) and videoconference increased knowledge for non-White participants as compared to White participants.
DISCUSSION
These data suggest that both telephone and videoconference are reasonable options for disclosure of APOE genotype in cognitively unimpaired individuals. Videoconference disclosure may have some benefits for certain demographic groups.
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This post is Copyright: | July 28, 2026
Neuro-Dementia