Abstract
INTRODUCTION
Air pollution is associated with dementia risk, but its role during preclinical Alzheimer’s disease (AD) remains unclear.
METHODS
We examined long-term residential exposure to traffic-related air pollution in 226 cognitively unimpaired middle-aged individuals at increased risk of AD from the ALzheimer’s and FAmilies ALFA+ cohort (a nested longitudinal cohort within the ALzheimer’s and Families parent cohort). Participants underwent baseline and 3-year follow-up cerebrospinal fluid (CSF) assessment of AD, neurodegeneration, astrocytic, microglial, and inflammatory biomarkers. Exposure to nitrogen dioxide (NO2), particulate matter (PM)10, PM2.5, and PM2.5 absorbance was estimated using land-use regression models. Sex-interaction and stratified analyses were performed. Mediation analyses evaluated cognitive and brain-age outcomes.
RESULTS
Sex-dependent associations were observed between air pollution exposure and CSF inflammatory and astrocytic biomarkers. Higher exposure was associated with longitudinal increases in glial fibrillary acidic protein (GFAP) and interleukin (IL) -6, primarily in women. GFAP partially mediated associations between air pollution exposure and worsening executive and attentional performance.
DISCUSSION
Findings support sex-specific astroglial and neuroinflammatory susceptibility to traffic-related air pollution in preclinical AD.
TRIAL REGISTRATION
The ALFA+ study has been registered at ClinicalTrials.gov (10-06-2015, identifier: NCT02485730).
If you do not see content above, kindly GO TO SOURCE.
Not all publishers encode content in a way that enables republishing at Neuro.vip.
This post is Copyright: | October 14, 2026
Neuro-Dementia