Abstract
INTRODUCTION
We investigated associations of Area Deprivation Index (ADI) with Alzheimer’s disease (AD) -related outcomes by biological and social factors in at-risk older adults.
METHODS
A total of 1880 U.S. POINTER participants with ADI and cognition (Preclinical Alzheimer’s Cognitive Composite [PACC]) were included. 868 had amyloid, tau positron emission tomography (PET), white matter hyperintensities (WMH), and/or gray matter volumes. We conducted exploratory, linear regression models testing ADI interactions with sex, race and ethnicity, and apolipoprotein E (APOE) ε4, adjusting for age and education.
RESULTS
“White/European American” and “Hispanic/Latinx/Spanish” showed lower cognitive scores with higher ADI, while “White/European American” showed the highest cognitive scores across ADI levels. APOE ε4 carriers from high-ADI areas showed higher WMH and tau, and “Hispanic/Latinx/Spanish” from more deprived areas showed higher WMH. Females from moderate-ADI areas showed higher tau. Amyloid burden was higher among low-ADI APOE ε4 carriers.
DISCUSSION
Differential associations of ADI with AD-related outcomes across biological and social factors may reflect systemic health disparities and study design.
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This post is Copyright: | November 1, 2026
Neuro-Dementia