Abstract
INTRODUCTION
Tau-positron emission tomography (PET) outcome data of patients with Alzheimer’s disease (AD) cannot currently be meaningfully compared or combined when different tracers are used due to differences in tracer properties, instrumentation, and methods of analysis.
METHODS
Using head-to-head data from five cohorts with tau PET radiotracers designed to target tau deposition in AD, we tested a joint propagation model (JPM) to harmonize quantification (units termed “CenTauR” [CTR]). JPM is a statistical model that simultaneously models the relationships between head-to-head and anchor point data. JPM was compared to a linear regression approach analogous to the one used in the amyloid PET Centiloid scale.
RESULTS
A strong linear relationship was observed between CTR values across brain regions. Using the JPM approach, CTR estimates were similar to, but more accurate than, those derived using the linear regression approach.
DISCUSSION
Preliminary findings using the JPM support the development and adoption of a universal scale for tau-PET quantification.
Highlights
Tested a novel joint propagation model (JPM) to harmonize quantification of tau PET.
Units of common scale are termed “CenTauRs”.
Tested a Centiloid-like linear regression approach.
Using five cohorts with head-to-head tau PET, JPM outperformed linearregressionbased approach.
Strong linear relationship was observed between CenTauRs values across brain regions.
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This post is Copyright: Antoine Leuzy,
Lars Lau Raket,
Victor L. Villemagne,
Gregory Klein,
Matteo Tonietto,
Emily Olafson,
Suzanne Baker,
Ziad S. Saad,
Santiago Bullich,
Brian Lopresti,
Sandra Sanabria Bohorquez,
Mercè Boada,
Tobey J. Betthauser,
Arnaud Charil,
Emily C. Collins,
Jessica A. Collins,
Nicholas Cullen,
Roger N. Gunn,
Makoto Higuchi,
Eric Hostetler,
R. Matthew Hutchison,
Leonardo Iaccarino,
Philip S. Insel,
Michael C. Irizarry,
Clifford R. Jack Jr,
William J. Jagust,
Keith A. Johnson,
Sterling C. Johnson,
Yashmin Karten,
Marta Marquié,
Sulantha Mathotaarachchi,
Mark A. Mintun,
Rik Ossenkoppele,
Ioannis Pappas,
Ronald C. Petersen,
Gil D. Rabinovici,
Pedro Rosa‐Neto,
Christopher G. Schwarz,
Ruben Smith,
Andrew W. Stephens,
Alex Whittington,
Maria C. Carrillo,
Michael J. Pontecorvo,
Samantha Budd Haeberlein,
Billy Dunn,
Hartmuth C. Kolb,
Sudhir Sivakumaran,
Christopher C. Rowe,
Oskar Hansson,
Vincent Doré | July 23, 2024