Abstract
INTRODUCTION
We disclosed amyloid positron emission tomography (PET) results in individuals with subjective cognitive decline (SCD) and studied patient experiences and outcomes over a 6-month period.
METHODS
Fifty-seven participants from the Subjective Cognitive Impairment Cohort (SCIENCe) (66 ± 8 years, 21 [37%] F, Mini-Mental State Examination 29 ± 1, 15 [26%] amyloid positive [A+]) completed questionnaires 1 week prior (T0), 1 day after (T1), and 6 months after amyloid PET disclosure (T2). Questionnaires addressed patient-reported experiences and outcomes.
RESULTS
Independent of amyloid status, participants were satisfied with the consultation (scale 1–10; 7.9 ± 1.7) and information provided (scale 1–4; T1: 3.3 ± 0.9, T2: 3.2 ± 0.8). After 6 months, A+ participants reported more information needs (45% vs. 12%, p = 0.02). Independent of amyloid status, decision regret (scale 1–5; A+: 1.5 ± 0.9, A−: 1.4 ± 0.6, p = 0.53) and negative emotions (negative affect, uncertainty, anxiety) were low (all p > 0.15 and Pinteraction
> 0.60).
DISCUSSION
Participants with SCD valued amyloid PET disclosure positively, regardless of amyloid status. The need for information after 6 months, which was stronger in A+ individuals, underscores the importance of follow-up.
Highlights
Participants with subjective cognitive decline (SCD) positively valued amyloid positron emission tomography (PET) disclosure.
Participants with SCD experienced low levels of decision regret.
We did not observe an increase in negative emotions.
After 6 months, amyloid-positive individuals wanted more information.
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This post is Copyright: Heleen M. A. Hendriksen,
Tanja J. de Rijke,
Agnetha Fruijtier,
Elsmarieke van de Giessen,
Argonde C. van Harten,
Mardou S. S. A. van Leeuwenstijn‐Koopman,
Jetske van der Schaar,
Calvin Trieu,
Denise Visser,
Ellen M. A. Smets,
Leonie N. C. Visser,
Wiesje M. van der Flier | August 1, 2024