Abstract
INTRODUCTION
Cardiovascular health is important for brain aging, yet its role in the clinical manifestation of autosomal dominant or atypical forms of dementia has not been fully elucidated. We examined relationships between Life’s Simple 7 (LS7) and clinical trajectories in individuals with autosomal dominant frontotemporal lobar degeneration (FTLD).
METHODS
Two hundred forty-seven adults carrying FTLD pathogenic genetic variants (53% asymptomatic) and 189 non-carrier controls completed baseline LS7, and longitudinal neuroimaging and neuropsychological testing.
RESULTS
Among variant carriers, higher baseline LS7 is associated with slower accumulation of frontal white matter hyperintensities (WMHs), as well as slower memory and language declines. Higher baseline LS7 associated with larger baseline frontotemporal volume, but not frontotemporal volume trajectories.
DISCUSSION
Better baseline cardiovascular health related to slower cognitive decline and accumulation of frontal WMHs in autosomal dominant FTLD. Optimizing cardiovascular health may be an important modifiable approach to bolster cognitive health and brain integrity in FTLD.
Highlights
Better cardiovascular health associates with slower cognitive decline in frontotemporal lobar degeneration (FTLD).
Lifestyle relates to the accumulation of frontal white matter hyperintensities in FTLD.
More optimal cardiovascular health associates with greater baseline frontotemporal lobe volume.
Optimized cardiovascular health relates to more favorable outcomes in genetic dementia.
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This post is Copyright: Anna M. VandeBunte,
Hyunwoo Lee,
Emily W. Paolillo,
Ging‐Yuek Robin Hsiung,
Adam M. Staffaroni,
Rowan Saloner,
Carmela Tartaglia,
Kristine Yaffe,
David S. Knopman,
Eliana Marisa Ramos,
Katya Rascovsky,
Andrea C. Bozoki,
Bonnie Wong,
Kimiko Domoto‐Reilly,
Allison Snyder,
Peter Pressman,
Mario F. Mendez,
Irene Litvan,
Julie A. Fields,
Douglas R. Galasko,
Ryan Darby,
Joseph C. Masdeu,
Maria Belen Pasqual,
Lawrence S. Honig,
Nupur Ghoshal,
Brian S. Appleby,
Ian R. Mackenzie,
Hilary W. Heuer,
Joel H. Kramer,
Adam L. Boxer,
Leah K. Forsberg,
Brad Boeve,
Howard J. Rosen,
Kaitlin B. Casaletto,
the ALLFTD Consortium | September 6, 2024