Abstract
INTRODUCTION
We investigated hippocampal synaptic density using synaptic vesicle 2A positron emission tomography (PET), and its association with amyloid beta (Aβ) and cognitive performance in healthy apolipoprotein E (APOE) ε4 carriers.
METHODS
Synaptic density was assessed in 46 individuals (APOE ε4/ε4 n = 14; APOE ε3/ε4 n = 16; APOE ε3/ε3 n = 16) with [11C]UCB-J-PET standardized uptake value ratios (SUVRs), by using the centrum semiovale as a reference region. Differences in hippocampal [11C]UCB-J SUVRs were analyzed with analysis of variance (ANOVA) and linear models. Associations among [11C]UCB-J SUVR, Aβ, hippocampal volume, and cognitive variables were analyzed with Spearman correlation.
RESULTS
Hippocampal synaptic density was different among the APOE groups (P
ANOVA = 0.016): APOE ε4/ε4 carriers had lower [11C]UCB-J SUVRs compared to APOE ε3/ε3 (p = 0.013). Hippocampal synaptic density did not correlate with Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) total score (rho = −0.052, p = 0.74), Alzheimer’s Prevention Initiative Preclinical Cognitive Composite (APCC) score (rho = 0.17, p = 0.28), or [11C]PiB uptake (rho = −0.10, p = 0.50).
DISCUSSION
Hippocampal synaptic loss emerges early in the AD continuum and is measurable in vivo in cognitively unimpaired high-risk individuals.
Highlights
Synaptic density was studied in vivo in healthy older adults using [11C]UCB-J positron emission tomography.
Apolipoprotein E (APOE) ε4/ε4 carriers had lower hippocampal synaptic density compared to APOE ε3/ε3.
Synaptic density was not associated with cognitive performance in this population.
Hippocampal synaptic alterations occur before clinical symptoms in APOE ε4/ε4 carriers.
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This post is Copyright: Anniina Snellman,
Jouni Tuisku,
Mikko Koivumäki,
Saara Wahlroos,
Richard Aarnio,
Johan Rajander,
Mira Karrasch,
Laura L. Ekblad,
Juha O. Rinne | October 30, 2024