Abstract
INTRODUCTION
The effects of sex and apolipoprotein E (APOE)—Alzheimer’s disease (AD) risk factors—on white matter microstructure are not well characterized.
METHODS
Diffusion magnetic resonance imaging data from nine well-established longitudinal cohorts of aging were free water (FW)–corrected and harmonized. This dataset included 4741 participants (age = 73.06 ± 9.75) with 9671 imaging sessions over time. FW and FW-corrected fractional anisotropy (FAFWcorr) were used to assess differences in white matter microstructure by sex and APOE ε4 carrier status.
RESULTS
Sex differences in FAFWcorr in projection tracts and APOE ε4 differences in FW limbic and occipital transcallosal tracts were most pronounced.
DISCUSSION
There are prominent differences in white matter microstructure by sex and APOE ε4 carrier status. This work adds to our understanding of disparities in AD. Additional work to understand the etiology of these differences is warranted.
Highlights
Sex and apolipoprotein E (APOE) ε4 carrier status relate to white matter microstructural integrity.
Females generally have lower free water–corrected fractional anisotropy compared to males.
APOE ε4 carriers tended to have higher free water than non-carriers.
If you do not see content above, kindly GO TO SOURCE.
Not all publishers encode content in a way that enables republishing at Neuro.vip.
This post is Copyright: Amalia Peterson,
Aditi Sathe,
Dimitrios Zaras,
Yisu Yang,
Alaina Durant,
Kacie D. Deters,
Niranjana Shashikumar,
Kimberly R. Pechman,
Michael E. Kim,
Chenyu Gao,
Nazirah Mohd Khairi,
Zhiyuan Li,
Tianyuan Yao,
Yuankai Huo,
Logan Dumitrescu,
Katherine A. Gifford,
Jo Ellen Wilson,
Francis E. Cambronero,
Shannon L. Risacher,
Lori L. Beason‐Held,
Yang An,
Konstantinos Arfanakis,
Guray Erus,
Christos Davatzikos,
Duygu Tosun,
Arthur W. Toga,
Paul M. Thompson,
Elizabeth C. Mormino,
Mohamad Habes,
Di Wang,
Panpan Zhang,
Kurt Schilling,
Alzheimer’s Disease Neuroimaging Initiative (ADNI),
The BIOCARD Study Team,
The Alzheimer’s Disease Sequencing Project (ADSP),
Marilyn Albert,
Walter Kukull,
Sarah A. Biber,
Bennett A. Landman,
Sterling C. Johnson,
Julie Schneider,
Lisa L. Barnes,
David A. Bennett,
Angela L. Jefferson,
Susan M. Resnick,
Andrew J. Saykin,
Timothy J. Hohman,
Derek B. Archer | December 23, 2024