Abstract
INTRODUCTION
Psychotropic medication (PM) use in behavioral-variant frontotemporal dementia (bvFTD) is higher than in other dementias. However, no information exists on whether PM use differs between sporadic and genetic bvFTD.
METHODS
We analyzed data from sporadic and genetic bvFTD participants with PM prescriptions in the Advancing Research and Treatment in Frontotemporal Lobar Degeneration/Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects study. We estimated ordinal odds ratio (OOR) of having more PM comparing sporadic and genetic bvFTD. Finally, we explored the neuropsychiatric symptom (NPS) combinations using classification and regression trees (CART).
RESULTS
We included 263 with sporadic and 193 with genetic bvFTD. The OOR for sporadic bvFTD to be on PM was 1.75 (95% confidence interval: 1.21 to 2.53) for the fully adjusted model. CART revealed the most common NPS combination was apathy + personality changes in 18% of participants.
DISCUSSION
Participants with sporadic bvFTD were twice as likely to be on PM compared to genetic bvFTD. The reason for increased PM usage in sporadic bvFTD participants should be further investigated.
Highlights
We report on patients with behavioral variant frontotemporal dementia (bvFTD).
We evaluated the psychotropic medication (PM) prescription at baseline in the cohort.
Patients with sporadic bvFTD had more prescriptions for PM than genetic patients.
The frequency of symptoms combination was different in sporadic and genetic bvFTD.
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This post is Copyright: Juan‐Camilo Vargas‐Gonzalez,
Nico Dimal,
Kasey Cortez,
Hilary Heuer,
Leah K. Forsberg,
Brian S. Appleby,
Sami Barmada,
Andrea Bozoki,
David Clark,
Yann Cobigo,
R. Ryan Darby,
Bradford C. Dickerson,
Kimiko Domoto‐Reilly,
Douglas R. Galasko,
Daniel H. Geschwind,
Nupur Ghoshal,
Neill R. Graff‐Radford,
Ian M. Grant,
David Irwin,
Ging‐Yuek Robin Hsiung,
Lawrence S. Honig,
Kejal Kantarci,
Gabriel C. Léger,
Irene Litvan,
Ian R. Mackenzie,
Joseph C. Masdeu,
Mario F. Mendez,
Chiadi U. Onyike,
Belen Pascual,
Peter Pressman,
Eliana Marisa Ramos,
Erik D. Roberson,
Emily Rogalski,
Brad F. Boeve,
Adam L. Boxer,
Howie J. Rosen,
Maria Carmela Tartaglia,
ALLFTD Consortium Investigators | December 23, 2024