Abstract
INTRODUCTION
We investigated the moderating effects of midlife and late-life cognitive activity (CA) on the relationship between tau pathology and both cognition and cognitive decline.
METHODS
Eighty-nine non-demented older adults from a Korean cohort underwent comprehensive evaluations, including CA assessments and tau neuroimaging at baseline, and Mini-Mental State Examination (MMSE) at baseline and the 2-year follow-up.
RESULTS
Greater midlife CA was associated with higher MMSE scores in a given amount of tau pathology, whereas higher levels of midlife CA were associated with faster tau-related decline in MMSE scores, particularly in individuals with mild cognitive impairment. Late-life CA did not exhibit any interaction with tau on either MMSE scores or their 2-year change.
DISCUSSION
Greater midlife CA is generally associated with better cognitive performance despite the presence of tau pathology. However, paradoxically, increased midlife CA appears to be linked to a more rapid tau-related cognitive decline in already cognitively impaired individuals.
Highlights
Greater midlife cognitive activity (CA) was generally associated with better cognitive performance in a given amount of tau pathology.
Paradoxically, higher levels of midlife CA were related to a more rapid tau-related cognitive decline in already cognitively impaired individuals.
Late-life CA did not exhibit any moderation effect on the association between tau and cognitive performance or decline.
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This post is Copyright: Kang Ko,
Dahyun Yi,
Min Soo Byun,
Joon Hyung Jung,
Nayeong Kong,
Gijung Jung,
Hyejin Ahn,
Yoon Young Chang,
Musung Keum,
Jun‐Young Lee,
Yun‐Sang Lee,
Yu Kyeong Kim,
Dong Young Lee,
for the KBASE Research Group | February 24, 2025