Abstract
INTRODUCTION
Dual cognitive and mobility decline is more strongly associated with dementia risk than cognitive decline only. It remains unknown whether this syndrome is associated with brain atrophy patterns, white matter (WM) damage, or pathology.
METHODS
In the Baltimore Longitudinal Study of Aging participants with and without dual decline, we used linear mixed-effects models to compare up to 13-year longitudinal changes in MRI-derived atrophy patterns, WM hyperintensities (n = 339), microstructure (n = 307), plasma glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), amyloid beta 42/40 (Aβ42/40) ratio (n = 349), and phosphorylated tau 181 (pTau181) (n = 258).
RESULTS
Those experiencing dual decline showed accelerated atrophy in medial temporal (p = .004), parietotemporal (p = .029), and perisylvian regions (p = .028), whereas gait decline only showed accelerated parietotemporal atrophy (p = .035) and memory decline only showed perisylvian atrophy (p = .021). Dual decline was also associated with unique microstructural deterioration in several WM tracts (p < .05), a greater decrease in Aβ42/40 ratio (p = .015), and greater increases in GFAP (p = .009) and NfL (p < .001).
DISCUSSION
Individuals experiencing dual decline are at an increased risk for regional brain atrophy, microstructural degradation, and biomarker-defined molecular changes underlying dementia.
Highlights
Those experiencing dual decline showed several accelerated brain atrophy patterns.
Those experiencing dual decline showed unique microstructural deterioration.
Dual decline showed a greater decline in plasma Aβ42/40 ratio.
Dual decline showed greater increases in plasma GFAP and NfL.
Dual decline may indicate brain and blood markers underlying dementia.
If you do not see content above, kindly GO TO SOURCE.
Not all publishers encode content in a way that enables republishing at Neuro.vip.
This post is Copyright: Qu Tian,
Erin E. Greig,
Keenan A. Walker,
Michael R. Duggan,
Zhijian Yang,
Abhay Moghekar,
Bennett A. Landman,
Christos Davatzikos,
Susan M. Resnick,
Luigi Ferrucci | February 24, 2025