Nature Neuroscience, Published online: 25 February 2025; doi:10.1038/s41593-025-01889-3Lipidomics revealed that neurons of patients with ALS/FTD have reduced levels of polyunsaturated fatty acid (PUFA)-containing phospholipids. Increasing neuronal PUFA levels increased survival of Drosophila models of ALS/FTD and patient neurons, suggesting that interventions that increase neuronal PUFA levels in patients with ALS/FTD may also be beneficial.
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This post is Copyright: Ashling Giblin | February 25, 2025
Nature Neuroscience