by Clinical Neuropsychologist Online | Friday, July 10, 2026 | Dementia
Abstract INTRODUCTION Memory is a strong endophenotype for Alzheimer’s disease (AD) but is typically detectable only after substantial brain change. Genetically linking late-life memory with mid-life brain traits may identify early markers of AD-related...
by Clinical Neuropsychologist Online | Friday, July 10, 2026 | Dementia
Abstract Gene-based therapies show increasing promise for the treatment of neurologic disease. In 2016, nusinersen, an RNA-based therapy, was approved for children with spinal muscular atrophy (SMA). Over 200 clinical trials have utilized gene therapy approaches for a...
by Clinical Neuropsychologist Online | Friday, July 10, 2026 | Dementia
Abstract INTRODUCTION We explored how people with dementia (PwD) and their carers navigate Peru’s health system for diagnosis and treatment. METHODS We interviewed PwD (n = 4), carers (n = 18), and healthcare workers (n = 17) from four sites. We developed a...
by Clinical Neuropsychologist Online | Friday, July 10, 2026 | Dementia
Abstract INTRODUCTION The Apolipoprotein E ε4 allele (APOE-ε4) is a well-established dementia risk factor among non-Latino White individuals but remains understudied among Asian Americans. We estimated its association with dementia risk among Chinese, Japanese,...
by Clinical Neuropsychologist Online | Friday, July 10, 2026 | Dementia
Abstract INTRODUCTION Perioperative neurocognitive disorder is a common and debilitating complication in the elderly, yet its cellular and molecular mechanisms in the aging brain remain poorly understood. METHODS Using aged mice, we examined the impact of abdominal...
